Well, I think the Riders wouldn't hurt themselves if they made a few changes which could possibly have to be made down the road if injury or poor play occur.
They should put in Lefall on the D-Line again and move Big Nate out not only to give him that extra week's rest but to give Lefall some more time just in case Nate does go down in playoffs Lefall will be up to game speed.
Put in Matt O'Meara instead of Childress. Childress is getting older and O'Meara is a good O-Lineman, once again there is a high probablity of Childress getting injured and this way his back-up will be up to speed.
Lastly, I say give Marcus the start but at the half if he's struggling or even if he's just playing an average game put Nealon in for the second half. Why? Well, seeing as Nealon hasn't taken a snap in close to three months now it may be a good idea to give him a little game time to get back to game-speed so just in case Marcus needs to be pulled in playoffs or if he even needs to go out for a few series Nealon is capable enough to do something productive with the Offence.
That's my take on it, but I'm not the coach and It'd be unlikely for any of these changes to take place.